Abstract

Study design: Retrospective study
Purpose: Comparison of baseline clinical and optical coherence tomography (OCT) features of posterior nodular scleritis (PNS) with large posterior choroidal granuloma (LPCG).
Methods: Retrospective, cross-sectional
Results: PNS comprised 11 eyes (10 cases); LPCG 10 eyes (10 cases). LPCG had mean age 28.7 years ±6.94 compared to PNS 41.70 years ±11.88. Inflammatory markers (outer retinal disruption, double layer sign, vitreous hyper reflective dots) we common in LPCG. Structural changes in inner retina and exudative changes were comparable in both groups. Choroid-scleral interface (CSI) at the edge of PNS lesion showed anterior bowing or ‘up the hill’ appearance while LPCG lesions showed posterior bowing or ‘down the hill’ appearance.
Conclusions: OCT diagnostic markers (direction of CSI) along with inflammatory markers in the vitreous and outer retina are helpful adjuvants in the differentiation of LPCG lesions from PNS.