Abstract

Purpose: To study the clinical & histopathological profile of choroidal melanoma treated with enucleation at our Centre
Study design: Retrospective case series
Methods: 50 cases of large choroidal melanoma were included. The mean age was 47.5 years, with 68% males & 32% females. Histopathologic examination showed spindle cell type to be the most common (48%), followed by epithelioid (26%) and mixed variety (26%). Scleral invasion was noted in 23 cases (46%), optic nerve (ON) invasion in 10 (20%) and ciliary body/iris invasion in 5 cases (10%).Spindle cell variety had a statistically significant association with ON invasion(p=0.03) while there was no correlation of tumor subtype with scleral (p=0.82) and anterior segment involvement (p=0.23).
Conclusion: Younger age at presentation & male preponderance was observed. The tumors showed a high propensity to invade the sclera and optic nerve. The spindle cell was the commonest subtype and found to be associated with optic nerve invasion.

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