Abstract

Purpose: To quantify microvascular changes using contrast-enhanced ultrasound (CEUS) technique for differentiating choroidal tumors
Study design: Prospective interventional
Methods: One patient with choroidal hemangioma (CH) and choroidal melanoma (CM) was selected for this study. Definity® was administered as a slow IV bolus (1 ml) followed by a normal saline 5 cc flush. CEUS was performed for two minutes post injection of the dye with continuous video recording. The mean intensity was calculated for each area, and compared pre- and post-injection frames.
Results: The time-averaged contrast increased by a percentage difference of 9.9% ± 5.2% (Mean ± SD) for CH and decreased by 4.2% ± 4.7% for CM. Furthermore, the intensity within the normal choroidal region was higher compared to the choroidal tumor region for both CH and CM.
Conclusions: CEUS can be a potentially promising tool for differentiating benign and malignant choroidal tumors.

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