Abstract

This is a cross-sectional study, which included patients with glaucoma who had been taking one/two/three topical drugs (minimum 3 months) and control group of newly diagnosed glaucoma. The patients were divided into test groups A1 (timolol 0.5% or brimonidine 0.2% or bimatoprost 0.03%), A2 (dual combination of any of the above drugs), A3 (triple combination) and control. Schirmer-I, tear film breakup time (TBUT), rose bengal, conjunctival impression cytology and ocular surface disease index (OSDI) scores were evaluated. A total of 102 patients were enrolled and divided into groups A1, A2, A3 and control, respectively. There was a significant difference in Schirmer’s test (mm), The mean TBUT results between the groups A1, A2, A3 and control, respectively; p<0.001). The mean OSDI scores were significantly (p<0.001) higher in A2 and A3 than A1.