Abstract

STUDY DESIGN: Prospective observational
PURPOSE: To evaluate the diagnostic utility of Angiotensin Converting Enzyme (ACE), Mantoux and lymphocyte count both in isolation and combined in clinical workup of uveitis patients.
METHOD: 95 uveitis patients were included. Outcome measures were sensitivity, specificity, positive predictive value(PPV) and negative predictive value(NPV) of the three tests in diagnosing ocular sarcoidosis and tuberculosis.
RESULTS
The sensitivity, specificity, PPV and NPV of elevated serum ACE in isolation to diagnose sarcoidosis were 89.5%, 69.7%, 42.5% and 96.4% respectively. But the sensitivity, specificity, PPV and NPV for elevated serum ACE, negative Mantoux and lymphopenia analyzed in combination for sarcoidosis were 5.26%, 100%, 100% and 80.9% respectively.
CONCLUSIONS: Combined correlation of elevated serum ACE, negative Mantoux and lymphopenia had a better ability to diagnose ocular sarcoidosis over tuberculosis owing to high specificity and PPV

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