Abstract

Purpose: To describe the rare occurrence of Rosai-Dorfman Disease presenting as an isolated conjunctival lesion. Methods: A retrospective analysis of Rosai-Dorfman Disease cases at our institute from 2000 to 2023. We documented cases with only conjunctival lesions, detailing clinical features, OCT findings, treatment approaches, and histopathological features.Results: We identified four cases with isolated conjunctival lesions. These growths were elevated, smooth, pinkish, with feeder vessels, with one bilateral involvement. ASOCT scans revealed subepithelial lesions with normal epithelium. No systemic involvement or palpable lymph nodes were found.. Histopathological examination confirmed Rosai-Dorfman Disease. Patients who had incisional biopsies were treated with topical steroids. All four patients had complete lesion resolution with no recurrence within one year.Conclusion: Isolated conjunctival Rosai-Dorfman Disease is rare, and systemic involvement is infrequent.