Abstract

Study design:retrospective
Purpose: To investigate the effect of HCQ drug in retinal electrical activity using mfERG
Methods: A hospital-based, retrospective study was done on 55 patients who were referred to the hospital for screening of HCQ drug toxicity between 2018 to 2022.A control group of 29 subjects without retinal disease and not on HCQ was selected & mfERG was performed and mfERG data was used for comparison with the HCQ group.
Results:110 eyes of 55 subjects taking HCQ with a mean age of 57.92 ± 1226 years and 58 eyes of 29 subjects were taken as the control group in this study. The Ring 1 P1 Response densities were significantly lower in HCQ patients compared to the scontrol group (P <0.001*). The Ring 2 P1 response densities and amplitude were also statistically significantly lower in the HCQ group when compared to the control group (P <0.001*).
Conclusion:mfERG demonstrated depression of signals in the parafoveal and central region in patients with HCQ use.

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