Abstract

Purpose: To report the clinicopathological features of corneal buttons in patients with corneal keloids.
Methods: The study involved a retrospective review of clinical features and corneal pathology examination of excised specimens through light microscopy and immunohistochemistry. Results: Nineteen eyes of 16 patients underwent corneal keloid excision and were categorized clinically into congenital (6), primary (6), and secondary (7). Three histological keloid patterns were identified: Type 1 (n=12), with myxomatous matrix and sparse collagen fibres; Type 2 (n=5), with thick bundles of irregularly arranged collagen; and a mixed type (n=2). Histologically, Bowman’s layer was absent, and smooth muscle actin-positive myofibroblasts with increased transforming growth factor-beta expression were observed in all specimens. Type 1 keloid showed increased keratan sulfate immunoreactivity. Descemet’s membrane and corneal endothelium were absent in 6 congenital keloid specimens.