Abstract
Study design: A prospective multi-center study.
Purpose: To determine the predictive value of baseline subfoveal choroidal thickness in diabetic macular edema (DME).
Methods: Patients with DME (n=95) treated with aflibercept had SFCT measured with OCT scans.
A functional responder was one with >5 ETDRS letter gain. An anatomical responder was one with SFCT reduction >25u.
Results: The mean SFCT decreased significantly after intervention. Multiple regression (after adjusting for confounders like age, gender, diabetes duration & Hba1c levels) revealed that higher SFCT had increased odds of having a better functional (OR=1.40, P=0.050) and anatomical outcome (OR=1.23, P=0.001), respectively. The mean vision gain in functional responders was 11 ETDRS letters and in anatomic responders was10 ETDRS letters (P<0.001). The vision gain in non responders was 5 and 6 ETDRS letters respectively.
Conclusion: A thicker baseline sub-foveal choroidal thickness may has a better response to treatment.
