FP1030 : Quantitative study of retinal circulation based on OCTA after plaque brachytherapy in uveal melanoma

  • Proceedings 2024
  • Free Paper
  • FP1030 : Quantitative study of retinal circulation based on OCTA after plaque brachytherapy in uveal melanoma
  • Chief AuthorDr.Neiwete Lomi
  • Co Author : Dr.Radhika Tandon, Prof. Dr.Bhavna Chawla, Dr.Rohan Chawla
  • Presenting Author : Dr. Zakir Hussain

Abstract

Purpose: To compare the micro-retinal circulation on OCT angiography in uveal melanoma patients after plaque brachytherapy with and without intravitreal bevacizumab (IVB)
Study design: Ambispective comparative
Methods: 10 patients each with and without prophylactic IVB were analyzed. Prospective group received IVB at the time of plaque removal, 2nd and 4th month post-op. OCTA peripapillary and macula changes were noted.
RESULTS: Significant OCTA changes were found at 6 months in between prospective versus retrospective group respectively in term of foveal avascular zone (FAZ) area (0.280 vs 0.706 (mm²) (p=0.009), Peripapillary capillary (PPC) perfusion & flux index {(PPC 42.87% vs 40.15%, p-0.018), Flux index: 0.372 vs 0.320, p-0.004}, ETDRS vessel density (EVD) (52.73% VS 12.9%, p=0.037).
Conclusion. OCTA revealed enlarged FAZ, reduced PPC & EVD in group without bevacizumab.

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