Abstract

Study Design: Retrospective case series
Purpose: To study the outcome in multi-drug resistant Pseudomonas aeruginosa (MDR-PA) keratitis/scleritis treated with colistin.
Methods: The records of 6 culture-proven MDR-PA keratitis patients, all exhibiting in vitro resistance by Kirby–Bauer disc diffusion method to ≥ three classes of routinely used topical antibiotics were reviewed. 5 patients had severe corneal ulcer with total melt at presentation and underwent therapeutic keratoplasty(TPK) and 1 patient had scleritis. 4/5 patients after TPK developed reinfection. All patients were given topical colistin 0.19% for a period of 10 weeks (average). 3/5 patients had scleral involvement after TPK and were given iv colistin for 1week along with subconjunctival colistin injections in addition to topical colistin 0.19%.
Results: Vascularized corneal opacity was achieved in 5/6 patients.
Conclusion: Collistin appears to be a promising treatment for MDR pseudomonas corneal ulcers.