Abstract

Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative spongiform encephalopathy caused by infectious agents called prions. It is a rapidly progressive disease with 100% mortality. Few patients initially present with visual symptoms.
This case report describes a 62-year-old female patient who presented with complaints of green-colored vision and the appearance of insects and hairs in left eye for 1 week. Her (BCVA) was 6/9. Ocular examination showed defective color vision & inability to perform central fields. Her pupils were brisk with normal fundus She denied hypertension, diabetes, psychosis, migraine, or epilepsy.
The patient was conscious with impaired cognition, disorientation, & anterograde memory loss. Gait disturbances and deranged mental functions suggested cortical insult. Magnetic resonance imaging (MRI) of the brain revealed ribbon-like plaques in the occipital cortex suggestive of prion protein (PrP) deposition and triphasic waves on electroencephalography (EEG)

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