Abstract

Purpose- To study ocular manifestations, severity and sequelae in SJS and TEN
Methods – Prospective study of 44 patients (30 SJS and 14 TEN). Ocular severity score (OSS) was assessed at baseline(acute) and at 6 months (chronic) and graded as mild, moderate and severe.
Results- Mean age was 28.15 ±15.78 years. Sixty five eyes of 33 patients were included. 38 patients (86.4%) had ocular manifestations. Drugs were common factor (95.4%). At baseline mild, moderate and severe OSS seen in 43.1%, 44.6% and 12.3%. At 6 months mild, moderate and severe OSS seen in 44.6%, 7.7% and 6.2% . Younger age group had higher chronic OSS. Patients with TEN had higher acute (p=0.001) and chronic (p=0.001) OSS than SJS. .
Conclusion- Greater severity of disease, more number of mucosal surfaces and shorter symptom lag correlated with more severe ocular manifestations. severity of lid margin involvement and corneal involvement were good predictors of severity of chronic ocular findings.