Abstract

Purpose: To find out correlation between severity of POAG and platelet parameters. Methods:200 POAG patients and 215 healthy controls were included. Blood samples for platelet parameters, including platelet count (PLT), platelet distribution width (PDW), plateletcrit (PCT), mean platelet volume (MPV), were analyzed . The POAG subgroups were classified according to age, gender and visual field mean deviation. Results: In POAG patients, PLT counts (207.08 ± 54.70 ∗109 /L) were significantly lower (p = 0.001) than those of the control group (220.46 ± 55.85 ∗109 /L). In the POAG group, PDW (13.76 ± 3.16 fL) and MPV (10.46 ± 1.32 fL) values were significantly higher (all p < 0.001) than those of the control group (PDW 11.82 ± 2.44 fL, MPV 10.13 ± 1.10 fL). Conclusion: PDW and MPV values were significantly elevated in POAG patients, and PDW was positively associated with disease severity, which suggested the possibility that platelet activation be involved in pathomechanisms of POAG

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