Abstract

Bisphosphonates are derived from an inorganic pyrophosphate and used in the treatment of osteoporosis due to their ability to decrease bone resorption caused by osteoclasts. The HORIZON trial in 2007 reported fever, myalgia, headache, arthralgia, or influenza-like symptoms in 32% of the people following the first dose of zolendronate injection. The estimated incidence of ocular inflammation (anterior uveitis or periorbital inflammation) is between 0.46% and 1%.This is a case report of a 60-year-old lady undergoing treatment for diabetes mellitus type 2 (since 2013), primary hypothyroidism (since 2011), and osteoporosis (postmenopausal since 2010) who presented to us 1 week after receiving Inj Zolendronic Acid 4 mg infusion with acute, bilateral anterior uveitis. She had no other systemic symptoms and no clinical history suggestive of any autoimmune diseases. She was treated with topical steroids, which resolved within a week.