Abstract

Purpose:To study the efficacy of interferon alpha 2b (INF α2b) for OSSN & its cost effectiveness.Materials & methods:Retrospective study of 45 patients with OSSN treated with topical INF α2b (1 MIU/cc) ± perilesional (5 MIU/cc)Result:The tumor involved cornea (n = 13, 30%), conjunctivo limbal (n = 30, 63%), bulbar conjunctiva (n=2, 7%).The mean basal dimension of the tumor was 9 mm.The tumor belonged to Tis (n = 9, 20%) or T3 (n = 36, 80%).In 9 patients with Tis, three cycles of topical INF α2b were used for immunoprevention. In the remaining 36 patients,INF α2b was advised for immunoreductio.Complete tumor regression by immunotherapy (n = 22) was achieved with a mean number of three topical INF α2b cycles and two perilesional injections. All these 22 patients received three additional topical INF α2b cycles after complete tumor regression.Conclusion:INF α2b can be used for immunoreduction,immunotherapy, & immunoprevention of OSSN.INFα2Ib is a cost effective treatment modality for OSSN