Abstract

Abstract:
Purpose: to evaluate the role on probiotics in improving the ocular surface health
Methods: 24 healthy subjects were divided in two groups – Combination group VE (Vibact®+Econorm®) and solo group V(Vibact®).Tear samples collected using Schirmer’s strips and 8 tear biomarkers were tested using the Biomarker Pathfinder® kit in each tear sample. Every subject had Schirmer’s test (ST1)done at baseline, 1 and 3 months.
Results: IL10 levels improved in 50% of VE eyes vs 29% in V after 3 months. VE group showed more reduction in MMP9, TNFa, and IL1b levels(83%, 50%, and 50% respectively) compared to V group(43%, 29%, and 14%).50% of VE eyes showed improvement in ST1 values compared to no improvement in V group.
Conclusion: Probiotics can improve ocular surface parameters by changing gut microbiota. The combination of beneficial bacterial species and yeast can enhance the tear film milieu, making it a potential treatment for ocular surface diseases.