Abstract

AIM Clinical features, treatment, efficacy of intravitreal Ranibizumab in Coats Disease
METHOD Case study of 6year old boy with dimness of vision in LE. A detailed history and complete examination with refraction, NCT, EUA, Fundus Photography, FFA, MRI, USG B-Scan, OCT were done followed by intravitreal Ranibizumab and laser.
RESULTS BCVA was 6/9 in RE, 2/60 in LE. Fundus showed subretinal & intraretinal exudation in macular region. FFA revealed abnormal inferotemporal vessels with telangiectasia and leakage. USG B-Scan shown calcific foci posteriorly. OCT revealed foveal thinning with CME. Ranibizumab was given in LE and vision improved from 2/60 to 6/36
CONCLUSION Coats disease is an idiopathic exudative retinopathy with abnormal retinal telangiectasia, oedema and lipid exudates in young males. After injection of Ranibizumab in LE, BCVA improved to 6/36. Thus Intravitreal anti-VEGF help in reduction of vascular permeability & edema which augment laser photocoagulation effectiveness.