Abstract

Design: Prospective interventional
Purpose: To study the efficacy of topical Cyclosporin A (CsA) 2% versus Tacrolimus ointment 0.15% in treating sub-epithelial infiltrates (SEI) following adenoviral keratoconjunctivitis (AKC).
Methods: 40 eyes with active SEI post-AKC were randomized into: Group I- 20 eyes on CsA 2 % (CsA 0.05%) eye drops, Group II-20 eyes on Tacrolimus (0.15% ointment) twice daily for 3 months. Topical Betamethasone 0.1% was given for initial 3 weeks. Topical loteprednol 0.2% was added in case of recurrence.
Results: Comparing CsA 2 % versus Tacrolimus 0.15%, final BCVA was 0.025 versus 0.015, p=0.695, decrease in SEI score by 2.05 versus 3.80, p=0.014 at 3 months respectively. Recurrence was seen in 17 eyes (85%) in CsA versus 9 eyes (45%)(Group2)
Conclusion: Steroid sparing aagents were ineffective in treating and decreasing the recurrences of sub-epithelial infiltrates. Tacrolimus ointment was relatively more effective (lesser SEI score and recurrence rate).