Abstract

DESIGN: Prospective Interventional study
Purpose : The author wishes to enhance the literature by assessing diffusion-weighted MRI of orbital muscle after administering 200 mg oral curcumin, to prove its role in TAO.
Methods: After institutional ethical clearance, prospective interventional data analysis was conducted on 17 cases of varying severity of thyroid-associated Ophthalmopathy over 6 months. Radiological reduction in the Apparent Diffusion Coefficient was the outcome parameter. ADC of extraocular muscles was analyzed at the presentation. Oral curcumin tablets were administered twice daily to the patients. Follow-up for radiological parameters was done at 6 months.
Results: At the end of 6 months, a significant reduction (p-value <0.05) in ADC of extra orbital muscles was noted.
Conclusion: Objective evidence of reduced ADC was found in our study, proving Curcumin as an effective adjunct modality in the treatment of TAO